Course and Time Roster – Fall 2011

Biological science majors must take this course for a letter grade. Email biomg1350@cornell.edu for enrollment information.

Problem Solving Sessions are strongly recommended: Monday or or Wednesday 8:30 - 10:00 AM. (3rd Session by arrangement with instructor).

Recommended prerequisite: BIOG 1500. Lab assignment made first day of class. Labs are held Tues, Wed, Thurs, and Fri 2:30-4:30pm. Problem solving sessions are strongly recommended: Tues or Wed 8:30-10am. (3rd sesion by arrangement with instructor). Not open to freshmen fall semester. View Prelim Schedule: http://registrar.sas.cornell.edu/Sched/exams.html

Prerequisite: one majors-level biology course and one year general chemistry, and CHEM 1570, or 3570-3580, or equivalents, or permission of instructor. CHEM 3580 may be taken concurrently. May not be taken for credit after BIOMG 3310, 3320, 3330, or 3350. Biological sciences majors must take course for a letter grade. Recommended co-requisite: BIOMG 3340. Organizational meeting Wednesday, August 24, 4:30 P.M. Baker Lab 200. Attendance is required. Evening Prelims fall and spring. View Prelim Schedule: http://registrar.sas.cornell.edu/Sched/exams.html

Prerequisite: one majors-level biology course and one year general chemistry and CHEM 1570 or 3570-3580 or equivalent, or permission of instructor (CHEM 1570 or 2570 should not be taken concurrently). An optional discussion section is held on most Fridays from 2:55-3:20pm. Evening Prelim. View Prelim Schedule: http://registrar.sas.cornell.edu/Sched/exams.html

Co-requisite: BIOMG 3300 or written permission of instructor. Organizational meeting Wednesday, August 24, 4:30PM 200 Baker Lab. Sections meet in G04 STM.

Co-requisite: BIOMG 3300 or written permission of instructor. Organizational meeting Wednesday, August 24, 4:30PM 200 Baker Lab. Sections meet in G04 STM.

Co-requisite: BIOMG 3300 or written permission of instructor. Organizational meeting Wednesday, August 24, 4:30PM 200 Baker Lab. Sections meet in G04 STM.

Prerequisite: BIOMG 2810 or permission of instructor.

Prerequsite: two majors-level biology courses and BIOMG 2810 or BIOMG 3300, or 3330, or 3350, or 3310/3320, or permission of instructor.

Prerequisite: BIOMG 3300, or 3330, or 3350, or 3310/3320, or written permission of instructor. Enrollment limited to: upper-classmen. Organizational meeting, first Tuesday of the semester, 4:15P 402 Biotech.

Prerequisite: two majors-level biology courses and BIOMG 3300, or 3330, or 3350, or 3310/3320. Recommended prerequisite: BIOMG 2810 and 4320.

Prerequisite: two majors-level biology courses and BIOMG 3300, or 3330, or 3350, or 3310/3320. Recommended prerequisite: BIOMG 2810 and 4320.

Prerequisite: BIOMG 3300, or 3330, or 3350, or 3310/3320 (at least one of 3310/3320 completed but one may be taken concurrently).

Prerequisite: BIOMG 3300, or 3330, or 3350, or 3310/3320 (at least one of 3310/3320 completed but one may be taken concurrently).

Prerequisite: BIOMG 1350 or ENTOM 2120 or permission of instructor.

Prerequisite: BIOMG 2810 and BIOMG 3300, BIOMG 3330, BIOMG 3350 or BIOMG 3320, or equivalents. Recommended prerequisite: BIOMG 3310.

Prerequisite: BIOMG 2810. Recommended prerequisite: BIOMI 2900 and BIOMG 3300, 3330 or 3350, or 3310/3320. The optional 1 credit is for registered students with permission of instructor to review literature.

Prerequisite: previous enrollment in course to be taught or equivalent. Arts students may not count this course toward graduation but may, upon petition (one time only) to their class dean, carry fewer than 12 other credits and remain in good standing. This would affect Dean's List eligibility but not eligibility for graduating with distinction. S-U or letter grades by permission of the instructor.

Prerequisite: BIOMG 2810 and BIOMG 3300, BIOMG 3320 or BIOMG 3330 or NS 3200.

Prerequisite: BIOMG 2810 or equivalent, BIOMG 3300 or BIOMG 3330 or BIOMG 3350 or BIOMG 3310 or equivalent, and permission of instructor. S-U grades by permission of instructor.

Brief description: This course will support the weekly seminar series in the department of Molecular Biology and Genetics (Fridays at 4:00, Biotechnology Building). At our initial meeting we will schedule one class participant for each MBG seminar (mbg.cornell.edu). This class participant will be responsible for contacting the seminar speaker a week or more in advance to inquire about a paper that will best capture the content of the MBG seminar. The participant will present the suggested paper along with suitable background information on the Wednesday before the Friday seminar. Students in this course will benefit from an enhanced experience at Friday seminar and also get a chance to communicate with scientists on the cutting-edge of research. Organization meeting will be 8/26/11. First meeting will be the week of 9/18/11.

This course will consist of 4 sessions of 1.5 hrs each focused on recent developments of biomedical importance in the field of DNA repair, replication, and recombination, as well as additional discussions sessions, related to the current literature. Specific topics to be covered may include: 1) DNA repair in stem cells; 2) New insights cancer into genomic instability and the origins of cancer from The Cancer Genome Atlas; 3) DNA damage and aging; 4) DNA repair pathways as targets for cancer therapy. Students enrolled for credit will be given one short writing assignment related to the course content. The specific meeting times for the course will be decided at the organizational meeting on Friday September 2nd at noon in T9006C Veterinary Research Tower.

Enrollment limited to: first year graduate students in the field of Genetics & Development.

Enrollment limited to: graduate students in Genetics & Development.

Enrollment limited to: students in Genetics & Development.

A prokaryotic RNA-based adaptive immune system known as CRISPR (clusters of regularly interspaced short palindromic repeats) was recently discovered. CRISPR drives adaptation to harmful invading nucleic acids - such as conjugative plasmids, transposable elements and phages - using an RNA-mediated defense mechanism with fundamental similarities to our innate and adaptive immune responses. CRISPR-Cas defense systems have been identified in 88% of archaeal genomes and 39% of bacterial genomes thus far sequenced, including important human pathogens such as Campylobacter jejuni, Clostridium botulinum, Escherichia coli, Listeria monocytogenes, Mycobacterium tuberculosis and Yersinia pestis. The significance of this pathway for human health is best illustrated in the human pathogen Staphylococcus epodermidis, where HGT through conjugation and plasmid transformation is prevented by CRISPR-Cas. This suggests that the CRISPR-Cas system can be exploited to limit the spread of antibiotic resistance in pathogenic bacteria due to HGT. In this course, we will explore the detailed molecular events of this defense system, specifically (i) adaptation upon first exposure to the foreign nucleic acid whereby some combination of CRISPR-associated (Cas) proteins extracts recognizable features from the genomes of viruses (bacteriophages) and plasmids as protospacers that are subsequently incorporated as spacers at the 5? end of genomic CRISPR loci; and (ii) interference upon re-exposure to the same nucleic acid whereby a ribonucleoprotein complex comprised of small guide RNAs derived from genomic CRISPRs and different Cas proteins targets foreign nucleic acids for destruction.

Single-stranded oligonucleotides (RNA, DNA, and modified nucleotide aptamers) have emerged as a powerful alternative protein and small molecule binding reagents that, like antibodies, show high affinity and specificity for their targets. Aptamers are selected against a target molecule using an iterative in vitro selection and amplification technique known as SELEX. Once isolated, these reagents can be engineered into reagents for detecting or inhibiting specific proteins both in vitro and in vivo. The short course covers the latest high efficiency approaches for generating aptamers and the engineering and application of these aptamers into high affinity detectors and inhibitors.

This course will consist of 4 sessions of 1.5 hrs each focused on recent developments of biomedical importance in the field of DNA repair, replication, and recombination. Specific topics to be covered may include: 1) DNA repair in stem cells; 2) New insights cancer into genomic instability and the origins of cancer from The Cancer Genome Atlas; 3) DNA damage and aging; 4) DNA repair pathways as targets for cancer therapy. Students enrolled for credit will be given one short writing assignment related to the course content. The specific meeting times for the course will be decided at the organizational meeting on Friday September 9 at noon in T9006C Veterinary Research Tower.

Students must register for both labs. Organizational meeting: first Friday of the semester.

Enrollment limited to: first semester Ph.D. students in the Graduate Field of BMCB.